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 Xuejun
Zhang |
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 Xuejun
Zhang M.D Ph.D
the professor of Dermatology and Venerology
President of Anhui Medical University
the superintendent of the Institute of Dermatology and Venerology
zhangxuejun@ahmu.edu.cn
tutor of MS and MD of the first affiliated hospital
of Anhui Medical University.
RESEARCH INTERESTS: Prof. Zhang have done many works in genetics of
dermatology. devoted to the study of genodermatoses and has published
his research results in the Journal of American Human Genetics, Human
Mutation, Journal of Investigative Dermatology, Journal of Clinical
Microbiology, Archive Dermatology, Journal of the American Academy
of Dermatology, British Journal of Dermatology, Journal of Dermatological
Science, Archive of Dermatology Research, Clinical and Experimental
Dermatology and International Journal of Dermatology. EDUCATION AND
TRAINING:
1976-1979, Department of Clinical Medicine,Anhui Medical University,
Bachelor
1986-1989, Department of Immunology£¬Anhui Medical University, MS.
1991-1994,Department of Dermatology,Huashan Hospital,Shanghai Medical
University, MD.
1995.6-7, Hokkaido University, Japans, Interview scholar
2000.6-9, Mayo Clinic, Harvard University, The United States, Interview
scholar
ACADEMIC APPOINTMENTS:
1980-1985, Anhui Medical University, Assistant
1990-1991, Anhui Medical University, Docent
1994-present, Anhui Medical University, professor£¬tutor of MD
1995-1997, Department of R&D, Anhui Medical University, Section
chief
1998-2001, Anhui Medical University, Vice president
2002-2003, Anhui Medical University, Vice secretariat of Party branch,
vice president£¨corporation£©
2003-present, Anhui Medical University, President, Vice secretariat
of Party branch
MAJOR GRANTS:
1. 1996, NSFC-Natural Science Foundation of China, The Target Antigen
of Basement Membrane Zone
2. 1998, NSFC-Natural Science Foundation of China, Psoriasis and
Its Receptor
3. 1999, China High-Tech Plan (863 Plan), Collection of Psoriasis
genetic resources and Study of Psoriasis susceptibility gene
4. 1999, Foundation of National backbone teachers of Ministry of
Education, Screening the gene mutations of anhidrotic ectodermal
dysplasia
5. 2001, China High-Tech Plan (863 Plan), Investigation of the Important
skin diseases genetic resources and gene research
6. 2001, International Foundation of AIDS, The community interfering
effect of AIDS
7. 2003, NSFC-Natural Science Foundation of China, The fine mapping
of vulgaris psoriasis susceptibility gene in Chinese Hans
HONORS:
1. 1996, Enjoyment the particular allowance of the State Council
2. 1997, Enrolled"Engineering of millions of person with ability"in
the first and second arrangements
3. 1996-2001, Won the Technological Third Prize of Anhui Province
three times
ACADEMIC POSITIONS:
1. Member, The Society for Investigative Dermatology £¨SID£©
2. Committeeman, The Membership Committee Member of International
Society of Dermatology (ISD)
3. the Vice Chairman, Chinese Society of Dermatology
4. the Chairman, The Adolescent Committee of Chinese Society of
Dermatology
5. the Chief Editor, Chinese Journal of Dermatology
6. Editorial Board Member, Chinese Journal of Medical Aesthetics
and Cosmetology
7. Editorial Board Member, Chinese Journal of Medical Genetics
8. Editorial Board Member, The Chinese Journal of Dermatovenereology
9. Editorial Board Member, Journal of Clinical Dermatology
10. Editorial Board Member, China Journal of Leprosy and Skin Diseases
11. Editorial Board Member, Foreign Medical Sciences---Section of
Dermatology and Venereology
12. Reviewer, British Journal of Dermatology
13. Editor, Journal of Investigative Dermatology
REPRESENTATIVE PUBLICATIONS:
1£®Editor in chief£¬1. The Textbook of Dermatology and Venerology,
The 5th edition£¬programming teaching material of the Ministry of
Sanitation and the Ministry of Education (2001)
2£®Editor in chief£¬the Foundation of Modern Dermatology. the popularize
book of the People Sanitation Book Concern in 9th five-years projection(2000)
3£®Editor in chief£¬The Development of Modern Dermatology and Venerulogy.
Anhui Science and Technology Book Concern(1997)
4£®Editor in chief£¬The Foundation and Clinic of Dermatoimmunology.
Shanghai Science and Technology Literature Book Concern (1996)
5£®Editor in chief£¬The Textbook of Dermatology the teaching material
for adult education, Henan Medical University Book Concern(1999)
6£®Editor in chief£¬Sexual translating Diseases and AIDS. The health
education reading matter for students in junior college and technical
secondary school, Anhui Educational Book Concern(2000)
7£®The treatises, reviews, lectures courses and case reports that
have been published in journals of China and other countries add
up to 126 pieces, and 7
of those papers were embodied by SCI.
RESEARCH PAPERS:
1. Chen JJ, Huang W, Gui JP, Yang S, Zhou FS, Xiong QG, Wu HB,
Cui Y, Gao M, Li W, Li JX, Yan KL, Yuan WT, Xu SJ, Liu JJ, Zhang
XJ. A novel linkage to generalized vitiligo on 4q13-q21 identified
in a genomewide linkage analysis of Chinese families. Am J Hum Genet,
2005 ;76(6).1057-1065 £¨correspondence author£¬IF 12.34/2004£©
2. Zhang XJ, He PP, Li M, He CD, Yan KL, Cui Y, Yang S, Zhang KY,
Gao M, Chen JJ, Li CR, Jin L, Chen HD, Xu SJ, Huang W. Seven novel
mutations of the ADAR gene in Chinese families and sporadic patients
with dyschromatosis symmetrica hereditaria (DSH). Hum Mutat, 2004;
23(6): 629-30.£¨correspondence author£¬IF 6.845/2004£©
3. Zheng GY, Hu LD, Huang W, Chen KD, Zhang XJ, Yang S, Sun JF,
Jiang YQ, Luo GB, Kong XY. CYLD mutation causes multiple familial
trichoepithelioma in three Chinese families. Hum Mutat, 2004;23(4):
400.£¨IF 6.845/2004£©
4. Zhang QP, Li Q, Hu CS, Zhang XL, Huang BJ, Yang MZ, Lao CM, He
JS, Gao QP, Zhang KJ, Sun ZM, Zhang XJ, Liu JY, Tan JQ. Selectively
increased expression and functions of chemokine receptor CCR9 on
CD4+ T cells from patients with T-cell lineage acute lymphocytic
leukemia. Cancer Research, 2003;63: 6469-77.£¨IF 7.69/2004£©
5. Zhang XJ, He PP, Wang ZX, Zhang J, Li YB, Wang HY, Wei SC, Chen
SY, Xu SJ, Jin L, Yang S, Huang W. Evidence for a major psoriasis
susceptibility locus at 6p21(PSORS1) and a novel candidate region
at 4q31 by genome-wide scan in Chinese Hans. J Invest Dermatol,
2002;119(6):1361-6.£¨correspondence author£¬IF 4.238/2004£©
6. Zhang XJ, Gao M, Li M, Li M, Li CR, Cui Y, He PP, Xu SJ, Xiong
XY, Wang ZX, Yuan WT, Yang S, Huang W. Identification of a locus
for dyschromatosis symmetrica hereditaria at chromosome 1q11-1q21.
J Invest Dermatol, 2003;120(5):776-80.£¨correspondence author£¬IF
4.238/2004£©
7. Zhang XJ, He PP, Liang YH, Yang S, Yuan WT, Xu SJ, Huang W. A
gene for freckles maps to chromosome 4q32-q34. J Invest Dermatol,
2004;122(2):286-90.£¨correspondence author£¬IF 4.238/2004£©
8. Zhang XJ, Liang YH, He PP, Yang S, Wang HY, Chen JJ, Yuan WT,
Xu SJ, Cui Y, Huang W. Identification of the cylindromatosis tumor-suppressor
gene responsible for multiple familial trichoepithelioma. J Invest
Dermatol, 2004;122(3):658-64.£¨correspondence author£¬IF 4.238/2004£©
9. Zhang XJ, Li M, Gao TW, He PP, Wei SC, Liu JB, Li CR, Cui Y,
Yang S, Yuan WT, Li CY, Liu YF, Xu SJ, Huang W. Identification of
a locus for punctate palmoplantar keratodermas at chromosome 8q24.13-8q24.21.
J Invest Dermatol, 2004; 122(5): 1121-5.£¨correspondence author£¬IF
4.238/2004£©
10. Wei SC, Yang S, Lin D, Li M, Zhang XQ, Bu L, Zheng GY, Hu LD,
Kong XY, Zhang XJ. A novel locus for disseminated superficial porokeratosis
maps to chromosome 18p11.3. J Invest Dermatol, 2004;123(5):872-5.£¨correspondence
author£¬IF 4.238/2004£©
11. Zhou WM, Du WD, Cao HM, Zhao JL, Yang S, Li W, Shen YJ, Zhang
SM, Du WH, Zhang XJ. Detection of gyrA and parC mutations associated
with ciprofloxacin resistance in Neisseria gonorrhoeae by use of
oligonucleotide biochip technology. J Clin Microbiol, 2004;42(12):
5819-24.£¨correspondence author£¬IF 3.439/2004£©
12. Zhang XJ, Liu JB, Gui JP, Li M, Xiong QG, Wu HB, Li JX, Yang
S, Wang HY, Gao M, Yang J, Yang Q. Characteristics of genetic epidemiology
and genetic models for vitiligo. J Am Acad Dermatol, 2004;51(3):383-90.£¨correspondence
author£¬IF 2.358/2004£©
13. Yang S, Yang J, Liu JB, Wang HY, Yang Q, Gao M, Liang YH, Lin
GS, Lin D, Hu XL, Fan L, Zhang XJ. The genetic epidemiology of alopecia
areata in China. Br J Dermatol, 2004;151(1):16-23.£¨correspondence
author£¬IF 2.445/2004£©
14. He PP, Zhang XJ, Yang Q, Li M, Liang YH, Yang S, Yan KL, Cui
Y, Shen YY, Wang HY, Sun LD, Du WH, Shen YJ, Xu SJ, Huang W. Refinement
of a locus for Marie Unna hereditary hypotrichosis to a 1.1-cM interval
at 8p21.3. Br J Dermatol, 2004;150(5):837-42.£¨correspondence author£¬IF
2.445/2004£©
15. He PP, He CD, Cui Y, Yang S, Xu HH, Li M, Yuan WT, Gao M, Liang
YH, Li CR, Xu SJ, Chen JJ, Chen HD, Huang W, Zhang XJ. Refined localization
of dyschromatosis symmetrica hereditaria gene to a 9.4-cM region
at 1q21-22 and a literature review of 136 cases reported in China.
Br J Dermatol, 2004;150(4):633-9.£¨correspondence author£¬IF 2.445/2004£©
16. Wei SC, Yang S, Li M, Song YX, Zhang XQ, Bu L, Zheng GY, Kong
XY, Zhang XJ. Identification of a locus for porokeratosis palmaris
et plantaris disseminata to a 6.9-cM region at chromosome 12q24.1-24.2.
Br J Dermatol, 2003;149(2):261-7.£¨correspondence author£¬IF 2.445/2004£©
17. Wang DB, Zhang XJ, Zhang HB, Zhang CY, Su B. A rapid assessment
of community-wide HIV/STI intervention in China. Sex Transm Infect,
2005;81(1):47-52.£¨correspondence author£¬IF 2.204/2004£©
18. Cui Y, Yang S, He PP, Zhou WM, Li M, Gao M, Chen JJ, Yan KL,
Xiao FL, Xu SJ, Huang W, Zhang XJ. Progressive symmetric erythrokeratodermia:
report of a Chinese family and evidence for genetic heterogeneity.
J Dermatol Sci, 2004;35(3):233-5.£¨correspondence author£¬IF 1.477/2004£©
19. Zhang XJ, Liu HS, Liang YH, Sun LD, Wang JY, Yang S, Liu JB,
Gao M, He PP, Cui Y, Yang Q. Association of HLA class I alleles
with vitiligo in Chinese Hans. J Dermatol Sci, 2004;35(2):165-8.£¨correspondence
author£¬IF 1.477/2004£©
20. Zhang XJ, Zhang AP, Yang S, Gao M, Wei SC, He PP, Wang HY, Song
YX, Cui Y, Chen JJ. Association of HLA class I alleles with psoriasis
vulgaris in southeastern Chinese Hans. J Dermatol Sci, 2003;33(1):1-6.£¨correspondence
author£¬IF 1.477/2004£©
21. Zhang XJ, Chen JJ, Yang S, Cui Y, Xiong XY, He PP, Dong PL,
Xu SJ, Li YB, Zhou Q, Wang Y, Huang W. A mutation in the connexin
30 gene in Chinese Han patients with hidrotic ectodermal dysplasia.
J Dermatol Sci, 2003;32(1):11-7.£¨correspondence author£¬IF 1.477/2004£©
22. Liang CZ, Zhang XJ, Hao ZY, Yang S, Wang DB, Shi HQ, Liu C.
An epidermiological study of patients with chronic prostatitis.
BJU Int, 2004;94(4): 568-70.£¨correspondence author£¬IF 2.089/2004£©
23. Yang S, Sun LD, Liu HS, Wang JY, He PP, Li M, Gao M, Liu JB,
Yang J, Wang ZX, Zhu YY, Lin D, Zhang XJ. A novel missense mutation
of the ATP2A2 gene in a Chinese family with Darier's disease. Arch
Dermatol Res, 2004;296(1):21-4.£¨correspondence author£¬IF 1.217/2004£©
24. Zhang XJ, Chen JJ, Song YX, Yang S, Xiong XY, Zhang AP, He PP,
Gao M, Li YB, Lin D, Huang W. Mutation analysis of the ED1 gene
in two Chinese Han families with X-linked hypohidrotic ectodermal
dysplasia. Arch Dermatol Res, 2003;295(1):38-42.£¨correspondence
author£¬IF 1.217/2004£©
25. Li M, Jiang YX, Liu JB, Yang S, He PP, Gao M, Wei SC, Yan KL,
Huang W, Zhang XJ. A novel mutation of the DSRAD gene in a Chinese
family with dyschromatosis symmetrica hereditaria. Clin Exp Dermatol,
2004;29(5):533-5.£¨correspondence author£¬IF 1.149/2004£©
26. Yan KL, He PP, Yang S, Li M, Yang Q, Ren YQ, Cui Y, Gao M, Xiao
FL, Huang W, Zhang XJ. Marie Unna hereditary hypotrichosis: report
of a Chinese family and evidence for genetic heterogeneity. Clin
Exp Dermatol, 2004;29(5):460-3.£¨correspondence author£¬IF 1.149/2004£©
27. Yang S, Ge HS, Zhang AP, Wei SC, Gao M, Wang HY, Chen JJ, Li
M, Liang YH, He PP, Yang J, Zhang XJ. Haplotype associations of
the MHC with psoriasis vulgaris in Chinese Hans. Clin Exp Dermatol,
2004;29(4):399-405.£¨correspondence author£¬IF 1.149/2004£©
28. Zhang XJ, Song YX, Zhang XQ, Yang S, Li M, Li CR, Yang CJ, Yang
J. A new glycine substitution mutation in the COL7A1 gene in a Chinese
family with dominant dystrophic epidermolysis bullosa. Clin Exp
Dermatol, 2003;28(4):437-9.£¨correspondence author£¬IF 1.149/2004£©
29. Yang S, Gao Y, Song YX, Liu JB, Yang CJ, Liu JL, Wang ZX, Zhang
XJ. The study of the participation of basement membrane zone antibodies
in the formation of the lupus band in systemic lupus erythematosus.
In J Dermatol, 2004;43(6): 420-7.£¨correspondence author£¬IF 0.884/2004£©
30. Zhang XJ, Wei SC, Yang S, Wang ZX, Zhang AP, He PP, Wang HY.
HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility
to psoriasis vulgaris in Chinese Han. In J Dermatol, 2004;43(3):
181-7.£¨correspondence author£¬IF 0.884/2004£©
31. Zhang XJ, Wang HY, Hsu Te-Shao, Yang S, Wang FX. Frequent use
of tobacco and alcohol in Chinese psoriasis patients. In J Dermatol,
2002;41: 659-62.£¨correspondence author£¬IF 0.884/2004£©
32. Zhang XJ, Wang HY, Hsu Te-Shao, Yang S, Chen SY. The genetic
epidermiology of psoriasis vulgaris in Chinese Han. In J Dermatol,
2002;41: 663-9.£¨correspondence author£¬IF 0.884/2004£©
33. Xiao SX, Wang XR, Qu BY, Yang MH, Liu GY, Bu L, Wang Y, Zhu
LQ, Lei H, Hu LD, Zhang XJ, Liu J, Zhao GP, Kong XY. Refinement
of the locus for autosomal dominant hereditary gingival fibromatosis(GINGF)
to a 3.8-cM region on 2p21. Genomics, 2000;68: 247-52£¨IF 3.840/2004£©
34. Yang S, Hu CS, Huang BJ, Zhang LJ, Li Q, Jiang S, Zhang QP,
Liu JY, Zhang XJ, Tan JQ. Aberration of CCR7+ CD8+ memory T cells
from patients systemic lupus erythematosus: an inducer of T helper
type 2 bias of CD4+ T cells. Immunology, 2004;112(2): 274-89.£¨IF
2.965/2004£©
35. Huang G, Niu TH, Peng SJ, Ling DJ, Lin J, Zhang XJ, Xu XP. Association
beween the interleukin-1¦ÂC(-511)T polymorphism and blood pressure
in a Chinese hypertensive population. Immunology Letter, 2004;91(2-3):
159-162£¨IF 2.136/2004£©
36. Liang CZ, Zhang XJ, Hao ZY, Shi HQ, Wang KX. Prevalence of sexual
dysfunction in Chinese men with chronic prostatitis. BJU Int, 2004;
93(4): 568-70.£¨IF 2.089/2004£©
37. Ye DQ, Hu YS, Li XP, Yang SG, Hao JH, Huang F, Zhang XJ. The
correlation between monocyte chemoattractant protein-1 and the arthritis
of systemic lupus erythematosus among Chinese. Arch Dermatol Res,
2005; 296(8): 366-371.£¨IF 1.217/2004£©
38. Ding CH, Li J, Zhang XJ. Bertilimumab Cambridge antibody technology
group£¨review£©. Curr Opin Investig Drugs, 2004;5(11): 1214-1218
39. Hao K, Peng SJ, Xing HX, Yu YX, Huang AQ, Hong XM, Wang YP,
Chen CZ, Wang BY, Zhang XJ, Liu J, Zhu GY, Huo Y, Chen DF, Zhao
XT, Ronnenberg A. Wu D, Niu TH, Xu XP. Beta3 adrenergic receptor
polymorphism and obeisity-related phenotypes in hypertensive patients.
Obes Res, 2004;12(1): 125-130£¨IF 3.701/2004£©
40. Hu Z, Wang DB, Liu HJ, Yang S, Ye DQ, Cao HT, Zhang XJ. STD/AIDS
knowledge, attitude, practice, and characteristics of market vendors
in Hefei, China. AIDS Patient Care and STDs, 2005;19(2): 121-126
£¨IF 1.600/2004£©
41. Yang S, Wang JY, Gao M, Liu HS, Sun LD, He PP, Liu JB, Zhang
AP, Cui Y, Liang YH, Wang ZX, Zhang XJ. Association of HLA-DQA1
and DQB1 genes with vitiligo in Chinese Hans. In J Dermatol, 2005;44£¨9£©£ºonline£¨IF
0.884/2004£©
42. Zhu QX, Shen T, Ding R, Liang CZ, Zhang XJ. Cytotoxicity of
trichloroethelene and perchloroethylene on normal human epidermal
keratinocytes and protective role of vitamine E. Toxicology, 2005;209(1):
55-67£¨correspondence author IF 2.691/2004£©
43. Gao M, Wang PG, Yang S, Hu XL, Zhang KY, Zhu YG, Ren YQ, Du
WH, Zhang GL, Cui Y, Chen JJ, Yan KL, Xiao FL, Xu SJ, Huang W, Zhang
XJ. Two frameshift mutation in the RNA-specific adenosine deaminase
gene association with dyschromotosis symmetrica hereditaria. Arch
Dermatol, 2005;141(2): 193-196£¨correspondence author, IF 3.187/2004£©
44. Xia Q, Yang S, Zhang SQ, Chen B, Wang DB, Zhu QX, Wang Y, Yan
KL, He PP, Zhang XJ. The effect of mizolastine on expression of
vascular endothelial cell growth factor, tumour necrosis factor-¦Á5
and keratinocytes-derived chemokine in murine mast cells compared
with dexmethasone and loratadine. Clin Exp Dermatol, 2005;30(2):165-170£¨correspondence
author£¬IF 1.149/2004£©
45. Zhu QX, Shen T, Tan D, Ding R, Liang CZ, Zhang XJ. Protective
effects of ginkgo biloba leaf extracts on trichloroethylene-induced
human keratinocytes cytotoxicity and apoptosis. Skin Pharmacol Physiol,
2005,18: 160-169£¨correspondence author£¬IF 1.358/2004£©
46. Cui Y, Wang J, Yang S, Gao M, Chen JJ, Yan KL, Xiao FL, Huang
W, Zhang XJ. Identification of a novel mutation in the DSRAD gene
in a Chinese pedigree with dyschromatosis symmetrica hereditaria.
Arch Dermatol Res,2005;296(11):543-545£¨correspondence author£¬IF
1.217/2004£©
47. Liu JB, Li M, Yang S, Gui JP, Wang HY, Du WH, Zhao XY, Ren YQ,
Zhu YG, Zhang XJ. Clinical profiles and associated diseases of vitiligo:
an analysis of 3742 patients in China. Clin Exp Dermatol,2005;30(5):327-331£¨correspondence
author£¬IF 1.149/2004£©
48. Gao M, Yang S, Li M, Yan KL, Jiang YX, Cui Y Xiao FL, Shen YX,
Chen JJ,Liu JB, Xu SJ, Huang W, Zhang XJ. Refined localization of
a punctate palmoplantar keratoderma gene to a 5.06-cM region at
15q22.2-15q22.31. Br J Dermatol. 2005 152(5):874-8. £¨correspondence
author£¬IF 2.445/2004)
49. Yang S, Zhang X, Liu J, Li M, Gui J, Wang H, Du W, Zhao X,Ren
Y,Zhu Y. An analysis of clinical manifestation and associated diseases
of vitiligo. J Invest Dermatol, 2005,124(4):39£¨IF 4.238/2004£©
50. Xiao FL, Yang S, Liu JB, He PP, Yang J, Cui Y, Yan KL, Gao M,
Liang YH, Zhang XJ. The epidemiology of childhood alopecia areata
in China: a study of 226 patients. Pediatric Dermatol, 2005;22(5):
in press£¨correspondence author£¬IF 0.783/2004£©
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